Zoloft Vs Prozac

Difference Between zoloft and prozac

Zoloft (Sertraline) and Prozac (Fluoxetine) both have a place with the SSRI (Selective Serotonin Reuptake Inhibitors) gathering of antidepressants. The impact and working of most SSRI are genuinely comparable, yet singular concoction synthesis of each medication figures out which works best for a particular individual on explicit manifestations.

Prozac comes as a postponed discharge fluoxetine hydrochloride tablet or as prepared for-utilize fluid, while Zoloft is sertraline hydrochloride that comes as a covered tablet or as the concentrated answer for being blended in with water. Generic version of Prozac is Fluoxetine. Generic version of Zoloft is Sertraline

Structure and Consumption

  • Both Zoloft (Sertraline) and Prozac (Fluoxetine) ought to be taken precisely as endorsed, ideally simultaneously every day. In light of the postponed release, it might take a month or longer for the impact to kick in. The utilization of these drugs ought not to be halted before first conversing with your primary care physician, as stopping to take them out of nowhere may bring about upsetting reactions.

    The two meds should be put away at room temperature, away from dampness and warmth.

Tablet structure

Zoloft (Sertraline): Should be taken with water. Sertraline (Zoloft) might be taken with or without food.

Prozac (Fluoxetine): An all-inclusive delivery Prozac container ought not to be broken, bitten, or opened. The pill ought to be gulped down as it is intended to deliver medication gradually in the body. Breaking the pill would make a lot of the medication be delivered at once.


Prozac (Fluoxetine) and Zoloft (Sertraline) both come in fluid-structure, yet fluid Prozac is prepared for consumption with no guarantees, while Zoloft arrives in a concentrated structure and should be weakened before the admission. One portion of Zoloft might be blended in with 4 ounces of water, soda, lemon/lime pop, lemonade, or squeezed orange – utilization of some other fluid to weaken the prescription isn’t suggested.

Zoloft versus Prozac: What's the distinction?

  • Zoloft and Prozac are specific serotonin reuptake inhibitor (SSRI) type antidepressants used to treat despondency, over the top urgent issue (OCD), alarm issue, and premenstrual dysphoric issue (PMDD).
  • Zoloft is additionally used to treat post-horrendous pressure issues (PTSD) and social tension issues.
  • Prozac is likewise used to treat bulimia, and it is additionally recommended in the mix with olanzapine (Zyprexa) to treat safe despondency and sadness related to bipolar confusion.
  • Symptoms of Zoloft and Prozac that are comparative incorporate tiredness/lethargy, rest issues (a sleeping disorder), sickness, skin rash, loss of hunger, and cerebral pain.
  • Symptoms of Zoloft that are not quite the same as Prozac incorporate drowsiness, apprehension, wooziness, quake, clogging, agitated stomach, loose bowels, irregular discharge, diminished enthusiasm for sexual movement, dry mouth, expanded perspiring, and weight reduction.
  • Symptoms of Prozac that are not quite the same as Zoloft incorporate uneasiness, vasculitis (irritation of little veins), and expanded circulatory strain.
  • Try not to quit utilizing Zoloft or Prozac abruptly, or you could have terrible withdrawal side effects.

How an SSRI Works?

To comprehend why medications like Zoloft and Prozac are recommended, why it is imperative to neither surpass the dose nor stop use abruptly, and how it very well may be inclined to substance misuse, it is critical to see how particular serotonin reuptake inhibitors take a shot at the cerebrum. This video clarifies the utilization of SSRI during despondency.


Basic reactions of SSRI drugs incorporate unfavorably susceptible side effects like skin rash or hives, trouble breathing, growing of your face, lips, tongue, or throat.


More genuine reactions incorporate state of mind or conduct changes, uneasiness, alarm assaults, inconvenience dozing, imprudent/eager inclination, peevishness, agitation, antagonism, animosity, hyperactivity (mental or physical), more extreme misery, self-destructive musings.

Clinical assistance ought to be looked for on the double at the indication of any new or exacerbating side effects like:

  • seizure (spasms)
  • quakes, shuddering, muscle solidness or jerking
  • issues with parity or coordination
  • Disturbance, disarray, perspiring, quick heartbeat.
  • Different less genuine yet more probable symptoms include:
  • tiredness, wooziness, shortcoming;
  • sickness, looseness of the bowels, changes in hunger;
  • Prozac has a couple of more symptoms notwithstanding the ones recorded previously:
  • a red, rankling, stripping skin rash;
  • runny nose, sore throat, migraine, influenza side effects;
  • weight changes;
  • Dry mouth expanded perspiring.
  • Measurements
  • SSRI ought to be taken in the exact endorsed sum; going astray from the portion sum can bring about genuine reactions.

Missing a portion

For either Prozac or Zoloft, a missed portion ought to be taken when you recollect, yet skipped if it’s nearly an ideal opportunity for the following planned portion. Try not to take additional medication to compensate for the missed portion


Look for crisis clinical consideration on the off chance that you think you have taken a lot of this Prozac or Zoloft.

Side effects of a fluoxetine (Prozac) overdose may incorporate queasiness, retching, fever, languor, fast or lopsided heartbeat, disarray, blacking out, seizures, or unconsciousness.

Side effects of sertraline (Zoloft) overdose may incorporate dizziness, laziness, queasiness, retching, fast heartbeat, disturbance, quake, disarray, seizures, and trance state.


Utilization of liquor or other rest initiating prescriptions (different meds that make you sluggish (cold/torment drug, muscle relaxers, medication for seizures, other medicine for sadness or uneasiness, opiate torment relievers) can build the force of symptoms of both Prozac and Zoloft, and ought to be evaded while on Prozac or Zoloft.

Zoloft and Prozac can both reason symptoms that may weaken your reasoning or responses. Activities that require center and readiness (driving, working hardware) ought to be dodged while on SSRI medicine.

Try not to take the fluid type of sertraline (Zoloft) in the event that you are taking disulfiram (Antabuse). Fluid sertraline may contain liquor and can start a serious response to disulfiram.

Are Zoloft and Prozac safe to utilize while pregnant or breastfeeding?


Utilization of Zoloft during the third trimester of pregnancy may prompt antagonistic impacts in the infant.

Utilization of Zoloft by nursing moms has not been sufficiently assessed.


Prozac should possibly be utilized during pregnancy if the potential advantage legitimizes the expected dangers to the hatchling.

Prozac is discharged in bosom milk. In this manner, the utilization of Prozac while nursing isn’t suggested.


Zoloft (sertraline) and Prozac (fluoxetine) are specific serotonin reuptake inhibitor (SSRI) type antidepressants used to treat gloom, over the top impulsive issue (OCD), alarm issue, and premenstrual dysphoric issue (PMDD). Zoloft is likewise used to treat post-awful pressure issues (PTSD) and social nervousness issues.

Prozac is additionally used to treat bulimia, and it is likewise recommended in the mix with olanzapine (Zyprexa) to treat safe sadness and melancholy connected with bipolar confusion.

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